If you are trying to upload or replace an asset in Astute Manager but the Upload icon is greyed out, this could mean that you have a file in your cloud storage that’s not present on your machine.
This could happen (for example) if you make some changes to your Keyboard Shortcuts file, and want to overwrite the one you had in the cloud with this new file.
The Astute Manager will display an orange marker to tell you the cloud file is not present on your machine, and will prompt you to re-download the older asset. If you want to replace this with the one you have saved locally, use the 3-dot menu to delete the Cloud Files. The Astute Manager will then allow you to re-upload the local newer file into the cloud.